abstract：:During organogenesis groups of differentiating cells self-organize into a series of structural intermediates with defined architectural forms. Evidence is emerging that such architectural forms are important in guiding cell fate, yet in vitro methods to guide cell fate have focused primarily on un-patterned exposure o...

journal_title：Biomaterials

authors： Soleas JP,D'Arcangelo E,Huang L,Karoubi G,Nostro MC,McGuigan AP,Waddell TK

更新日期：2020-09-01 00:00:00

abstract：:Healing soft-tissue wounds with an irregular, complicated topography in a bleeding environment demands the development of a dressing that is wet-adhesive, haemostatic, and antibacterial. To meet this unmet demand, we designed a flexible nanosheet (~77 nm thick) made of two layers, one is the antibacterial and haemosta...

journal_title：Biomaterials

authors： Xuan C,Hao L,Liu X,Zhu Y,Yang H,Ren Y,Wang L,Fujie T,Wu H,Chen Y,Shi X,Mao C

更新日期：2020-09-01 00:00:00

abstract：:Although synergistic therapy for tumors has displayed significant promise for effective treatment of cancer, developing a simple and effective strategy to build a multi-functional nanoplatform is still a huge challenge. By virtue of the characteristics of tumor microenvironment, such as hypoxia, slight acidity and H2O...

journal_title：Biomaterials

authors： Wang M,Chang M,Chen Q,Wang D,Li C,Hou Z,Lin J,Jin D,Xing B

更新日期：2020-09-01 00:00:00

abstract：:Nowadays, limited deep tumor penetration and lower therapeutic effect are still the major obstacle in nanomedicines for cancer therapy. Here, we developed high-efficiency nanocomposites, SO2 prodrug (BTS) loaded Au-Ag hollow nanotriangles (Au-Ag-BTS HTNs), which could not only synergistically upregulate Bax expression...

journal_title：Biomaterials

authors： Xu M,Lu Q,Song Y,Yang L,Li J,Li N

更新日期：2020-08-01 00:00:00

abstract：:The biophysical properties of extracellular matrices (ECM) are known to regulate cell behavior, however decoupling cell behavior changes due to the relative contributions of material microstructure versus biomechanics or nutrient permeability remains challenging, especially within complex, multi-material matrices. We ...

journal_title：Biomaterials

authors： Dubbin K,Robertson C,Hinckley A,Alvarado JA,Gilmore SF,Hynes WF,Wheeler EK,Moya ML

更新日期：2020-08-01 00:00:00

abstract：:The nanopore size and roughness of nanoporous surface are two critical variables in determining stem cell fate, but little is known about the contribution from each cue individually. To address this gap, we use two-dimensional nanoporous membranes with controlled nanopore size and roughness to culture bone marrow-deri...

journal_title：Biomaterials

authors： Xia J,Yuan Y,Wu H,Huang Y,Weitz DA

更新日期：2020-07-01 00:00:00

abstract：:Ex-vivo blood-brain barrier (BBB) model is of great value for studying brain function and drug development, but it is still challenging to engineer macroscale three-dimensional (3D) tissue constructs to recapitulate physiological and functional aspects of BBB. Here, we describe a delicate 3D vascularized neural constr...

journal_title：Biomaterials

authors： Yue H,Xie K,Ji X,Xu B,Wang C,Shi P

更新日期：2020-07-01 00:00:00

abstract：:Craniofacial skeletal muscle is composed of approximately 60 muscles, which have critical functions including food uptake, eye movements and facial expressions. Although craniofacial muscles have significantly different embryonic origin, most current skeletal muscle differentiation protocols using human induced plurip...

journal_title：Biomaterials

authors： Kim E,Wu F,Wu X,Choo HJ

更新日期：2020-07-01 00:00:00

abstract：:High sensitivity at ultra-high field (UHF) and sufficient potential to penetrate the brain are the most desirable characteristics in the development of contrast agents (CAs) for magnetic resonance imaging (MRI). However, incorporating such qualities into a single nanocarrier is challenging. Herein, we report a new str...

journal_title：Biomaterials

authors： Kim HK,Baek AR,Choi G,Lee JJ,Yang JU,Jung H,Lee T,Kim D,Kim M,Cho A,Lee GH,Chang Y

更新日期：2020-06-01 00:00:00

abstract：:In vitro tissue engineered models are poised to have significant impact on disease modeling and preclinical drug development. Reliable methods to induce microvascular networks in such microphysiological systems are needed to improve the size and physiological function of these models. By systematically engineering sev...

journal_title：Biomaterials

authors： Brown A,He H,Trumper E,Valdez J,Hammond P,Griffith LG

更新日期：2020-06-01 00:00:00

abstract：:Pancreatic cancer is predicted to be the second leading cause of cancer-related death by 2025. The best chemotherapy only extends survival by an average of 18 weeks. The extensive fibrotic stroma surrounding the tumor curbs therapeutic options as chemotherapy drugs cannot freely penetrate the tumor. RNA interference (...

journal_title：Biomaterials

authors： Kokkinos J,Ignacio RMC,Sharbeen G,Boyer C,Gonzales-Aloy E,Goldstein D,Australian Pancreatic Cancer Genome Initiative Apgi,McCarroll JA,Phillips PA

更新日期：2020-05-01 00:00:00

abstract：:Ferroptosis, a newfound non-apoptotic cell death pathway, results from the accumulation of iron-dependent lipid peroxide (LPO). Recently, emerging iron-based nanomaterials have been extensively developed to induce Fenton reaction-dependent ferroptosis for cancer therapy. However, insufficient amount of H2O2 and limite...

journal_title：Biomaterials

authors： He YJ,Liu XY,Xing L,Wan X,Chang X,Jiang HL

更新日期：2020-05-01 00:00:00

abstract：:Nanobubbles, as a kind of new ultrasound contrast agent (UCAs), have shown promise to penetrate tumor vasculature to allow for targeted imaging. However, their inherent physical instability is an ongoing concern that could weaken their imaging ability with ultrasound. Gas vesicles (GVs), which are genetically encoded,...

journal_title：Biomaterials

authors： Wang G,Song L,Hou X,Kala S,Wong KF,Tang L,Dai Y,Sun L

更新日期：2020-04-01 00:00:00

abstract：:Nanomaterials with integrated multiple imaging and therapeutic modalities possess great potentials in accurate cancer diagnostics and enhanced therapeutic efficacy. Traditional strategies for achieving multimodality nanoplatform through one by one combination of different modalities are challenged by the complicated s...

journal_title：Biomaterials

authors： He X,Peng C,Qiang S,Xiong LH,Zhao Z,Wang Z,Kwok RTK,Lam JWY,Ma N,Tang BZ

更新日期：2020-04-01 00:00:00

abstract：:Exosomes have emerged as appealing candidate therapeutic agents and delivery nanoplatforms due to their endogenous features and unique biological properties. However, obstacles such as low isolation yield, considerable complexity and potential safety concerns, and inefficient drug payload substantially hamper their th...

journal_title：Biomaterials

authors： Lu M,Huang Y

更新日期：2020-03-02 00:00:00

abstract：:Tumor cells interact with the microenvironment that specifically supports and promotes tumor development. Key components in the tumor environment have been linked to various aggressive cancer features and can further influence the presence of subpopulations of cancer cells with specific functions, including cancer ste...

journal_title：Biomaterials

authors： Landberg G,Fitzpatrick P,Isakson P,Jonasson E,Karlsson J,Larsson E,Svanström A,Rafnsdottir S,Persson E,Gustafsson A,Andersson D,Rosendahl J,Petronis S,Ranji P,Gregersson P,Magnusson Y,Håkansson J,Ståhlberg A

更新日期：2020-03-01 00:00:00

abstract：:Nanocarrier for augmenting the efficacy of reactive oxygen species (ROS) by tumor microenvironment (TME) has become an emerging strategy for cancer treatment. Herein, a smart biodegradable drug delivery nanoplatform with mitochondrial-targeted ability, pH-responsive drug release and enzyme-like catalytic function is d...

journal_title：Biomaterials

authors： An J,Hu YG,Cheng K,Li C,Hou XL,Wang GL,Zhang XS,Liu B,Zhao YD,Zhang MZ

更新日期：2020-03-01 00:00:00

abstract：:Multiple ophthalmic pathologies, such as retinal detachment and diabetic retinopathy, require the removal and replacement of the vitreous humor. Clinical tamponades such as silicone oil and fluorinated gases are utilized but limited due to complications and toxicity. Therefore, there is a need for biocompatible, stabl...

journal_title：Biomaterials

authors： Raia NR,Jia D,Ghezzi CE,Muthukumar M,Kaplan DL

更新日期：2020-03-01 00:00:00

abstract：:Self-assembly is a prominent phenomenon observed in nature. Inspired by this thermodynamically favorable approach, several natural and synthetic materials have been investigated to develop functional systems for various biomedical applications, including drug delivery. Furthermore, layered self-assembled systems provi...

journal_title：Biomaterials

authors： Sarode A,Annapragada A,Guo J,Mitragotri S

更新日期：2020-02-29 00:00:00

abstract：:Zwitterionic hydrogels such as those based on polycarboxybetaine (PCB) or polysulfobetaine (PSB) have potential for various biomedical applications, due to their biocompatibility and low biofouling properties. However, the poor mechanical properties of zwitterionic hydrogels developed to date remain a challenge, sever...

journal_title：Biomaterials

authors： Liu Q,Chiu A,Wang L,An D,Li W,Chen EY,Zhang Y,Pardo Y,McDonough SP,Liu L,Liu WF,Chen J,Ma M

更新日期：2020-02-01 00:00:00

abstract：:The incidence of Parkinson's disease (PD), the second most common neurodegenerative disorder, has increased exponentially as the global population continues to age. Although the etiological factors contributing to PD remain uncertain, its average incidence rate is reported to be 1% of the global population older than ...

journal_title：Biomaterials

authors： Karthivashan G,Ganesan P,Park SY,Lee HW,Choi DK

更新日期：2020-02-01 00:00:00

abstract：:Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and...

journal_title：Biomaterials

authors： Cheng R,Liu L,Xiang Y,Lu Y,Deng L,Zhang H,Santos HA,Cui W

更新日期：2020-02-01 00:00:00

abstract：:Photosensitizers with aggregation-induced emission (AIE) characteristics are of great interest for cancer theranostics involving both fluorescence imaging and photodynamic therapy (PDT). However, in the purpose of clinical trials of PDT, the development of prominent drug delivery systems for boosting the PDT efficienc...

journal_title：Biomaterials

authors： Li Y,Wu Q,Kang M,Song N,Wang D,Tang BZ

更新日期：2020-02-01 00:00:00

abstract：:Gd3+-based contrast agents monopolize in the clinical MR imaging-based diagnosis of hepatic tumors, however, the inherent toxicity by the released Gd3+-ions triggered an urgent demand for safer alternatives. Here, we demonstrate hollow manganese silicate nanoparticles (HMS), which exert burst-release of Mn2+-ions by s...

journal_title：Biomaterials

authors： Kim JG,Jang MS,Kumari N,Choi JK,Im GH,Kwon T,Lee JH,Lee WJ,Lee IS

更新日期：2020-02-01 00:00:00

abstract：:Drug-loaded implants have attracted considerable attention in cancer treatment due to their precise delivery of drugs into cancer tissues. Contrary to injected drug delivery, the application of drug-loaded implants remains underutilized given the requirement for a surgical operation. Nevertheless, drug-loaded implants...

journal_title：Biomaterials

authors： Yang Y,Qiao X,Huang R,Chen H,Shi X,Wang J,Tan W,Tan Z

更新日期：2020-02-01 00:00:00

abstract：:The nanotopography and nanoscale geometry of the extra-cellular matrix (ECM) are important regulators of cell adhesion, motility and fate decision. However, unlike the sensing of matrix mechanics and ECM density, the molecular processes regulating the direct sensing of the ECM nanotopography and nanoscale geometry are...

journal_title：Biomaterials

authors： Di Cio S,Iskratsch T,Connelly JT,Gautrot JE

更新日期：2020-02-01 00:00:00

abstract：:Tissue engineering generally utilizes natural or synthetic scaffolds to repair or replace damaged tissues. However, due to the lack of guidance of biological signals, most of the implanted scaffolds have always suffered from poor in vivo cellularization. Herein, we demonstrate a bio-orthogonal reaction-based strategy ...

journal_title：Biomaterials

authors： Mao D,Zhang C,Kenry,Liu J,Wang X,Li B,Yan H,Hu F,Kong D,Wang Z,Liu B

更新日期：2020-02-01 00:00:00

abstract：:Modeling the interaction between the supportive stroma and the hematopoietic stem and progenitor cells (HSPC) is of high interest in the regeneration of the bone marrow niche in blood disorders. In this work, we present an injectable co-culture system to study this interaction in a coherent in vitro culture and in viv...

journal_title：Biomaterials

authors： Tavakol DN,Tratwal J,Bonini F,Genta M,Campos V,Burch P,Hoehnel S,Béduer A,Alessandrini M,Naveiras O,Braschler T

更新日期：2020-02-01 00:00:00

abstract：:Umbilical cord mesenchymal stem cells (UCMSCs) have shown great potentials in regenerative medicine for their extensive sources, multilineage differentiation potential, low immunogenicity and self-renewal ability. However, the clinical application of UCMSCs still confronts many challenges including the requirement of ...

journal_title：Biomaterials

authors： Qiao Y,Xu Z,Yu Y,Hou S,Geng J,Xiao T,Liang Y,Dong Q,Mei Y,Wang B,Qiao H,Dai J,Suo G

更新日期：2020-01-01 00:00:00

abstract：:Chemodynamic therapy (CDT) has recently emerged as a promising treatment for cancer due to the high specificity of CDT towards tumor microenvironment (TME). However, the low efficiency of reactive oxygen species (ROS) generation and the robust ROS defensive mechanisms in cancer cells remain critical hurdles for curren...

journal_title：Biomaterials

authors： Wang S,Yang L,Cho HY,Dean Chueng ST,Zhang H,Zhang Q,Lee KB

更新日期：2019-12-01 00:00:00

abstract：:Neuromuscular circuits (NMCs) are vital for voluntary movement, and effective models of NMCs are needed to understand the pathogenesis of, as well as to identify effective treatments for, multiple diseases, including Duchenne's muscular dystrophy and amyotrophic lateral sclerosis. Microfluidics are ideal for recapitul...

journal_title：Biomaterials

authors： Bellmann J,Goswami RY,Girardo S,Rein N,Hosseinzadeh Z,Hicks MR,Busskamp V,Pyle AD,Werner C,Sterneckert J

更新日期：2019-12-01 00:00:00

abstract：:Nowadays, two-dimensional (2D) nanomaterials with many fascinating physicochemical properties have drawn extensive attention as drug delivery platforms for cancer theranostics. Nevertheless, current existing 2D nanomaterial-based drug delivery systems normally undergo the bottlenecks of hash preparation process, low d...

journal_title：Biomaterials

authors： Liu F,Lin L,Zhang Y,Sheng S,Wang Y,Xu C,Tian H,Chen X

更新日期：2019-12-01 00:00:00

abstract：:The widespread use of synthetic transvaginal polypropylene mesh for treating Pelvic Organ Prolapse (POP) has been curtailed due to serious adverse effects highlighted in 2008 and 2011 FDA warnings and subsequent legal action. We are developing new synthetic mesh to deliver endometrial mesenchymal stem cells (eMSC) to ...

journal_title：Biomaterials

authors： Emmerson S,Mukherjee S,Melendez-Munoz J,Cousins F,Edwards SL,Karjalainen P,Ng M,Tan KS,Darzi S,Bhakoo K,Rosamilia A,Werkmeister JA,Gargett CE

更新日期：2019-12-01 00:00:00

abstract：:As a chronic and lifelong disease, obesity not only significant impairs health but also dramatically shortens life span (at least 10 years). Obesity requires a life-long effort for the successful treatment because a number of abnormalities would appear in the development of obesity. Nanomaterials possess large specifi...

journal_title：Biomaterials

authors： Li J,Cha R,Luo H,Hao W,Zhang Y,Jiang X

更新日期：2019-12-01 00:00:00

abstract：:Hepatocytes derived from human pluripotent stem cells (hPSCs) are promising candidates for cell therapy and drug discovery. However, it remains challenging to efficiently purify hepatocytes from undesired cell types after differentiation and to accurately monitor grafted cells after transplantation. Indocyanine Green ...

journal_title：Biomaterials

authors： Park JY,Han J,Jung HS,Lee G,Kim HJ,Cho GS,Park HJ,Han C,Kim JS,Kim JH

更新日期：2019-11-01 00:00:00

abstract：:Natural particles ranging from various cell membranes to nascent proteins are highly optimized for their specific functions in vivo and possess features that are desired in drug delivery carriers. However, the current endeavor in research on bioparticles is still seeking the appropriate strategy to shield multiple age...

journal_title：Biomaterials

authors： Wang R,Zhang C,Li J,Huang J,Opoku-Damoah Y,Sun B,Zhou J,Di L,Ding Y

更新日期：2019-11-01 00:00:00

abstract：:Prostate cancer (PCa) is a leading cause of death for men worldwide. Most PCa patients die from metastasis and bone is the most common metastatic site. Three dimensional (3D) porous chitosan-alginate (CA) scaffolds were developed for bone tissue engineering and demonstrated for culture of cancer cells and enrichment o...

journal_title：Biomaterials

authors： Xu K,Ganapathy K,Andl T,Wang Z,Copland JA,Chakrabarti R,Florczyk SJ

更新日期：2019-10-01 00:00:00

abstract：:Therapeutic options to treat primary glioblastoma (GBM) tumors are scarce. GBM tumors with epidermal growth factor receptor (EGFR) mutations, in particular a constitutively active EGFRvIII mutant, have extremely poor clinical outcomes. GBM tumors with concurrent EGFR amplification and active phosphatase and tensin hom...

journal_title：Biomaterials

authors： Pedron S,Wolter GL,Chen JE,Laken SE,Sarkaria JN,Harley BAC

更新日期：2019-10-01 00:00:00

abstract：:Patient-derived tumor organoids offer potentially useful models of cancer tissue physiology. Yet, conventional organoid cultures utilize generic matrices that are difficult to tailor for various unique tumor microenvironments. Here, we employ synthetic, enzymatically crosslinked hydrogels to define mechanical and bioc...

journal_title：Biomaterials

authors： Ng S,Tan WJ,Pek MMX,Tan MH,Kurisawa M

更新日期：2019-10-01 00:00:00

abstract：:Nitric oxide (NO) is widely known as an effective vasodilator at low concentrations. Drug delivery systems combined with NO can dilate blood vessels surrounding tumor tissues, and the drug accumulation in tumors is accelerated by the enhanced permeability and retention effect, leading to an improvement in the anti-tum...

journal_title：Biomaterials

authors： Kang Y,Kim J,Park J,Lee YM,Saravanakumar G,Park KM,Choi W,Kim K,Lee E,Kim C,Kim WJ

更新日期：2019-10-01 00:00:00